Topic leaderboard
Microorganisms, enzymes & genetic engineering
Ranked by the PatentIndex Score — a 1–99 percentile within C12N · public-visibility date · generated 2026
top 25 per window · public-visibility date
Rising· last 2 yrs
Inventors whose newest C12N patents became public in the last 2 years — the current frontier
- 199Feng Zhang171 patents · 16,312 citations
- 296Stanislaw Flasinski148 patents · 7,196 citations
- 392Casey C. Case40 patents · 8,376 citations
- 488Muthiah Manoharan206 patents · 14,179 citations
- 583Carl H. June118 patents · 14,666 citations
- 679Leonard G. Presta54 patents · 7,371 citations
- 775Daniel J. Capon31 patents · 7,020 citations
- 871Gary J. Nabel77 patents · 9,028 citations
- 967Fei Ran18 patents · 3,948 citations
- 1063Ganesh M. Kishore63 patents · 9,624 citations
- 1158Sayda M. Elbashir57 patents · 3,736 citations
- 1254Guangping Gao115 patents · 6,544 citations
- 1350Michael Weiner48 patents · 3,147 citations
- 1446Robert Osborne29 patents · 3,562 citations
- 1542Richard Jude Samulski67 patents · 7,360 citations
- 1638Terry R. Wright49 patents · 2,652 citations
- 1733Antonin De Fougerolles100 patents · 4,871 citations
- 1829George M. Church115 patents · 4,708 citations
- 1925Andrew J. Murphy246 patents · 4,885 citations
- 2021Yi-Ju Chen11 patents · 1,380 citations
- 2117Derek Jantz56 patents · 2,244 citations
- 2213James Jefferson Smith59 patents · 2,242 citations
- 238Ian Maclachlan40 patents · 4,541 citations
- 244David R. Liu144 patents · 7,864 citations
- 251Narendra S. Yadav66 patents · 4,973 citations
Active· last 5 yrs
Sustained C12N output across the last 5 years
- 199Marianne Malven30 patents · 7,984 citations
- 296Feng Zhang171 patents · 16,312 citations
- 392Jennifer Rinehart11 patents · 6,504 citations
- 488Willem P. Stemmer27 patents · 9,036 citations
- 583John Mccafferty25 patents · 7,999 citations
- 679Stanislaw Flasinski148 patents · 7,196 citations
- 775Casey C. Case40 patents · 8,376 citations
- 871Arthur M. Krieg55 patents · 7,726 citations
- 967Aya Jakobovits71 patents · 10,850 citations
- 1063Ellen Dickinson7 patents · 5,259 citations
- 1158Nancy Taylor7 patents · 5,259 citations
- 1254Muthiah Manoharan206 patents · 14,179 citations
- 1350Le Cong22 patents · 4,382 citations
- 1446Carl H. June118 patents · 14,666 citations
- 1542Leonard G. Presta54 patents · 7,371 citations
- 1638Paul C. C. Feng38 patents · 6,131 citations
- 1733Daniel J. Capon31 patents · 7,020 citations
- 1829Gary J. Nabel77 patents · 9,028 citations
- 1925Fei Ran18 patents · 3,948 citations
- 2021Steven H. Bass23 patents · 6,894 citations
- 2117Ganesh M. Kishore63 patents · 9,624 citations
- 2213Glenn K. Fu38 patents · 3,361 citations
- 238Stephen P. A. Fodor30 patents · 3,300 citations
- 244James M. Wilson182 patents · 13,721 citations
- 251Jeffrey A. Hubbell51 patents · 7,711 citations
All-time canon
Career PatentIndex Score in C12N
- 199Nils Lonberg39 patents · 36,407 citations
- 296Robert M. Kay26 patents · 34,550 citations
- 392Robert Charles Ladner49 patents · 15,692 citations
- 488Arthur C. Ley21 patents · 15,155 citations
- 583Rachel Kent13 patents · 14,902 citations
- 679Marianne Malven30 patents · 7,984 citations
- 775Gregory Paul Winter43 patents · 16,852 citations
- 871Sonia Guterman13 patents · 14,426 citations
- 967Philip Felgner37 patents · 14,278 citations
- 1063Feng Zhang171 patents · 16,312 citations
- 1158Jennifer Rinehart11 patents · 6,504 citations
- 1254William Markland11 patents · 13,633 citations
- 1350Willem P. Stemmer27 patents · 9,036 citations
- 1446Andrew David Griffiths49 patents · 14,643 citations
- 1542James D. Marks25 patents · 8,815 citations
- 1638John Mccafferty25 patents · 7,999 citations
- 1733Stanislaw Flasinski148 patents · 7,196 citations
- 1829Casey C. Case40 patents · 8,376 citations
- 1925Hendricus Renerus Jacobus Mattheus Hoogenboom29 patents · 10,121 citations
- 2021Stephen P. Eisenberg23 patents · 6,818 citations
- 2117George N. Cox, Iii13 patents · 5,850 citations
- 2213Eric Jarvis20 patents · 4,525 citations
- 238Sharon Kaye Spratt9 patents · 4,029 citations
- 244Arthur M. Krieg55 patents · 7,726 citations
- 251Geoffrey Walter Grigg7 patents · 4,880 citations
Rising· last 2 yrs
The top-scoring C12N patents made public in the last 2 years
- 199US12134770B1✦ AIComposition for regulating production of interfering ribonucleic acid87 cites · 202493% earned
- 296US12018274B2✦ AICompositions and methods for regulating production of a fusion protein and ribonucleic aci79 cites · 202493% earned
- 392US11933957B1✦ AIImaging system hardware47 cites · 202475% earned
- 488US11970739B2Multiplex capture of gene and protein expression from a biological sample45 cites · 202485% earned
- 583US12281309B1Composition for regulating production of interfering ribonucleic acid28 cites · 202591% earned
- 679US12195747B1Composition for regulating production of interfering ribonucleic acid39 cites · 202575% earned
- 775US12117439B2Compositions and methods for using fixed biological samples34 cites · 202484% earned
- 871US11926822B1Three-dimensional spatial analysis48 cites · 202492% earned
- 967US12097263B2Muscle targeting complexes and uses thereof for treating myotonic dystrophy18 cites · 202481% earned
- 1063US11969475B2Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dyst25 cites · 202475% earned
- 1158US12005124B2Muscle targeting complexes and uses thereof for treating dystrophinopathies23 cites · 202473% earned
- 1254US12018087B2Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an o23 cites · 202477% earned
- 1350US12012460B2Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an o22 cites · 202471% earned
- 1446US12440837B2Devices and methods for analyzing biological samples7 cites · 202564% earned
- 1542US12180453B2Systems, devices, and methods for electroporation within a cell processing system13 cites · 202483% earned
- 1638US11999947B2Adenosine nucleobase editors and uses thereof18 cites · 202477% earned
- 1733US12031126B2Methods and compositions for simultaneous editing of both strands of a target double-stran18 cites · 202481% earned
- 1829US12128109B2Muscle targeting complexes and formulations for treating dystrophinopathies17 cites · 202484% earned
- 1925US12246266B2Disposable for a spray drying system16 cites · 202478% earned
- 2021US12286673B2Increasing efficiency of spatial analysis in a biological sample15 cites · 202480% earned
- 2117US12169198B2Systems and methods for sample analysis15 cites · 202483% earned
- 2213US11987838B2Methods and kits for labeling cellular molecules13 cites · 202461% earned
- 238US12371688B2Methods, compositions, and systems for spatial analysis of analytes in a biological sample8 cites · 202468% earned
- 244US12329825B1Muscle targeting complexes comprising an anti-transferrin receptor antibody linked to an o4 cites · 202570% earned
- 251US12281306B1Composition for regulating production of interfering ribonucleic acid7 cites · 202586% earned
Active· last 5 yrs
The top-scoring C12N patents of the last 5 years
- 199US12134770B1✦ AIComposition for regulating production of interfering ribonucleic acid87 cites · 202493% earned
- 296US11162132B2✦ AISpatially distinguished, multiplex nucleic acid analysis of biological specimens146 cites · 202181% earned
- 392US11352659B2✦ AIMethods of detecting analytes139 cites · 202278% earned
- 488US11512308B2Nucleic acid library methods108 cites · 202284% earned
- 583US11618897B2Methods, compositions, and systems for capturing probes and/or barcodes97 cites · 202282% earned
- 679US11592447B2Spatially-tagged analyte capture agents for analyte multiplexing96 cites · 202285% earned
- 775US11407992B2Methods of determining a surgical margin and methods of use thereof116 cites · 202284% earned
- 871US11530423B1Composition for regulating production of ribonucleic acid83 cites · 202293% earned
- 967US12018274B2Compositions and methods for regulating production of a fusion protein and ribonucleic aci79 cites · 202493% earned
- 1063US11624086B2Simultaneous spatio-temporal measurement of gene expression and cellular activity93 cites · 202287% earned
- 1158US11739381B2Multiplex capture of gene and protein expression from a biological sample72 cites · 202286% earned
- 1254US10953089B1Coronavirus vaccine formulations99 cites · 202183% earned
- 1350US11447770B1Methods and compositions for prime editing nucleotide sequences81 cites · 202278% earned
- 1446US11933957B1Imaging system hardware47 cites · 202475% earned
- 1542US11732300B2Increasing efficiency of spatial analysis in a biological sample73 cites · 202186% earned
- 1638US12281309B1Composition for regulating production of interfering ribonucleic acid28 cites · 202591% earned
- 1733US11873505B2Compositions and methods for regulating production of a precursor protein81 cites · 202289% earned
- 1829US11111309B2Method of reducing expression of DUX4 in a muscle cell by administering an anti-transferri65 cites · 202177% earned
- 1925US12195747B1Composition for regulating production of interfering ribonucleic acid39 cites · 202575% earned
- 2021US11467153B2Methods for processing nucleic acid molecules62 cites · 202188% earned
- 2117US11369689B2Muscle targeting complexes and uses thereof for treating dystrophinopathies48 cites · 202277% earned
- 2213US12071655B2Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysi36 cites · 202387% earned
- 238US11638761B2Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dyst47 cites · 202383% earned
- 244US12117439B2Compositions and methods for using fixed biological samples34 cites · 202484% earned
- 251US11241493B2Coronavirus vaccine54 cites · 202192% earned
All-time canon
The defining C12N patents of the whole record
- 199US4816567A✦ AIRecombinant immunoglobin preparations13,882 cites · 198993% earned
- 296US4683202A✦ AIProcess for amplifying nucleic acid sequences13,211 cites · 198796% earned
- 392US5223409A✦ AIDirected evolution of novel binding proteins6,875 cites · 199389% earned
- 488US5523520AMutant dwarfism gene of petunia6,136 cites · 199696% earned
- 583US5545806ARansgenic non-human animals for producing heterologous antibodies5,538 cites · 199696% earned
- 679US5569825ATransgenic non-human animals capable of producing heterologous antibodies of various isoty4,704 cites · 199696% earned
- 775US5633425ATransgenic non-human animals capable of producing heterologous antibodies4,435 cites · 199796% earned
- 871US5625126ATransgenic non-human animals for producing heterologous antibodies4,338 cites · 199796% earned
- 967US4179337ANon-immunogenic polypeptides4,333 cites · 197996% earned
- 1063US5545807AProduction of antibodies from transgenic animals4,332 cites · 199696% earned
- 1158US5661016ATransgenic non-human animals capable of producing heterologous antibodies of various isoty4,236 cites · 199796% earned
- 1254US4965188AProcess for amplifying, detecting, and/or cloning nucleic acid sequences using a thermosta3,972 cites · 199096% earned
- 1350US5565332AProduction of chimeric antibodies - a combinatorial approach3,895 cites · 199696% earned
- 1446US6737056B1Polypeptide variants with altered effector function3,376 cites · 200487% earned
- 1542US4816397AMultichain polypeptides or proteins and processes for their production3,126 cites · 198996% earned
- 1638US6506559B1Genetic inhibition by double-stranded RNA3,119 cites · 200387% earned
- 1733US5580859ADelivery of exogenous DNA sequences in a mammal3,073 cites · 199689% earned
- 1829US4235871AMethod of encapsulating biologically active materials in lipid vesicles3,061 cites · 198096% earned
- 1925US5403484AViruses expressing chimeric binding proteins2,866 cites · 199588% earned
- 2021US5571698ADirected evolution of novel binding proteins2,681 cites · 199688% earned
- 2117US5770429ATransgenic non-human animals capable of producing heterologous antibodies2,663 cites · 199896% earned
- 2213US5939598AMethod of making transgenic mice lacking endogenous heavy chains2,618 cites · 199992% earned
- 238US5968830ASoybean transformation and regeneration methods2,571 cites · 199996% earned
- 244US5589466AInduction of a protective immune response in a mammal by injecting a DNA sequence2,447 cites · 199689% earned
- 251US4399216AProcesses for inserting DNA into eucaryotic cells and for producing proteinaceous material2,439 cites · 198396% earned
Rising· last 2 yrs
Assignees whose newest C12N patents became public in the last 2 years — the current frontier
- 199GENENTECH INC938 patents · 51,832 citations
- 296MONSANTO TECHNOLOGY LLC1,933 patents · 29,123 citations
- 392BROAD INST INC239 patents · 14,092 citations
- 488UNIV IOWA RES FOUND156 patents · 12,846 citations
- 583UNIV PENNSYLVANIA686 patents · 21,494 citations
- 679SCRIPPS RESEARCH INST362 patents · 16,239 citations
- 775US HEALTH927 patents · 26,269 citations
- 871WISCONSIN ALUMNI RES FOUND592 patents · 13,224 citations
- 967NOVO NORDISK AS360 patents · 16,965 citations
- 1063UNIV COLUMBIA303 patents · 11,535 citations
- 1158UNIV CALIFORNIA1,940 patents · 41,504 citations
- 1254UNIV TEXAS657 patents · 19,279 citations
- 1350HARVARD COLLEGE653 patents · 22,178 citations
- 1446REGENERON PHARMA585 patents · 8,345 citations
- 1542PIONEER HI BRED INT1,729 patents · 26,904 citations
- 1638PURDUE RESEARCH FOUNDATION160 patents · 8,058 citations
- 1733MAX PLANCK GESELLSCHAFT157 patents · 3,634 citations
- 1829UNIV MASSACHUSETTS355 patents · 7,071 citations
- 1925MASSACHUSETTS INST TECHNOLOGY536 patents · 18,497 citations
- 2021GILEAD SCIENCES INC70 patents · 4,920 citations
- 2117OSIRIS THERAPEUTICS INC47 patents · 8,091 citations
- 221310X GENOMICS INC146 patents · 6,323 citations
- 238GENZYME CORP213 patents · 7,851 citations
- 244CALIFORNIA INST OF TECHN331 patents · 7,616 citations
- 251UNIV WASHINGTON443 patents · 12,215 citations
Active· last 5 yrs
Sustained C12N output across the last 5 years
- 199GENENTECH INC938 patents · 51,832 citations
- 296MONSANTO TECHNOLOGY LLC1,933 patents · 29,123 citations
- 392BROAD INST INC239 patents · 14,092 citations
- 488UNIV IOWA RES FOUND156 patents · 12,846 citations
- 583UNIV PENNSYLVANIA686 patents · 21,494 citations
- 679SCRIPPS RESEARCH INST362 patents · 16,239 citations
- 775US HEALTH927 patents · 26,269 citations
- 871WISCONSIN ALUMNI RES FOUND592 patents · 13,224 citations
- 967NOVO NORDISK AS360 patents · 16,965 citations
- 1063UNIV COLUMBIA303 patents · 11,535 citations
- 1158UNIV CALIFORNIA1,940 patents · 41,504 citations
- 1254UNIV TEXAS657 patents · 19,279 citations
- 1350CORNELL RES FOUNDATION INC251 patents · 10,574 citations
- 1446US NAVY43 patents · 6,730 citations
- 1542HARVARD COLLEGE653 patents · 22,178 citations
- 1638REGENERON PHARMA585 patents · 8,345 citations
- 1733PIONEER HI BRED INT1,729 patents · 26,904 citations
- 1829PURDUE RESEARCH FOUNDATION160 patents · 8,058 citations
- 1925MAX PLANCK GESELLSCHAFT157 patents · 3,634 citations
- 2021UNIV MASSACHUSETTS355 patents · 7,071 citations
- 2117DHARMACON INC86 patents · 5,005 citations
- 2213DU PONT825 patents · 19,060 citations
- 238MASSACHUSETTS INST TECHNOLOGY536 patents · 18,497 citations
- 244GILEAD SCIENCES INC70 patents · 4,920 citations
- 251SALK INST FOR BIOLOGICAL STUDI181 patents · 6,941 citations
All-time canon
All-time PatentIndex Score in C12N
- 199GENENTECH INC938 patents · 51,832 citations
- 296GENPHARM INT22 patents · 35,725 citations
- 392MONSANTO TECHNOLOGY LLC1,933 patents · 29,123 citations
- 488AFFYMAX TECH NV18 patents · 13,450 citations
- 583MEDICAL RES COUNCIL103 patents · 16,980 citations
- 679PROTEIN ENG CORP5 patents · 13,691 citations
- 775BROAD INST INC239 patents · 14,092 citations
- 871SANGAMO BIOSCIENCES INC130 patents · 11,908 citations
- 967UNIV IOWA RES FOUND156 patents · 12,846 citations
- 1063ISIS PHARMACEUTICALS INC559 patents · 48,069 citations
- 1158CETUS CORP75 patents · 22,569 citations
- 1254VICAL INC34 patents · 10,223 citations
- 1350ABGENIX INC21 patents · 10,043 citations
- 1446MAXYGEN INC90 patents · 23,382 citations
- 1542UNIV PENNSYLVANIA686 patents · 21,494 citations
- 1638SCRIPPS RESEARCH INST362 patents · 16,239 citations
- 1733US HEALTH927 patents · 26,269 citations
- 1829WISCONSIN ALUMNI RES FOUND592 patents · 13,224 citations
- 1925MONSANTO CO183 patents · 24,064 citations
- 2021NOVO NORDISK AS360 patents · 16,965 citations
- 2117LYNX THERAPEUTICS INC21 patents · 5,886 citations
- 2213UNIV COLUMBIA303 patents · 11,535 citations
- 238UNIV CALIFORNIA1,940 patents · 41,504 citations
- 244PLANT GENETIC SYSTEMS NV63 patents · 7,195 citations
- 251UNIV TEXAS657 patents · 19,279 citations
90–99 field-defining50–89 strong<50 emergingearned by citationsfrom family breadth